Ebook Introduction to Proteins: Structure, Function, and Motion, Second Edition (Chapman & Hall/CRC Mathematical and Computational Biology)
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Introduction to Proteins: Structure, Function, and Motion, Second Edition (Chapman & Hall/CRC Mathematical and Computational Biology)
Ebook Introduction to Proteins: Structure, Function, and Motion, Second Edition (Chapman & Hall/CRC Mathematical and Computational Biology)
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Review
Praise for the 1st edition "I’ve just lately used this textbook for a presentation on electrostatics. Although I have an organic background, I discovered that the explanations of electrostatic interactions are very clear and informative. The language isn’t too technical and may be easily understood by biology students. The textbook covers numerous examples and colorful illustrations, which made it easy to understand the principles discussed. The book is well organized in chapters for all the fundamental topics. I feel this book would be appropriate for any undergraduate and graduate scholar who’s keen on proteins. … It’s complete, easy to observe and (something I at least discover uncommon for textbooks) pleasing to read. The authors don’t shrink back from any subjects, but clarify things in a straightforward method supported by ample examples. Highly recommended."―Physics Book Reviews at dowdawgs.com, May 2013 Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. …The book is clear, well organized, aptly illustrated in color, and a pleasure to read. The first two chapters are an impressive textbook unto themselves … The book is thoroughly documented with citations to the literature gathered at the end of each chapter. … Overall, this is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field.―Eric Martz, Biochemistry and Molecular Biology Education, Vol. 40, 2012 This is an important book. … This book captures in a very accessible way a growing body of literature on the structure, function and motion of proteins, and links this to more established paradigms such as a reader might find in a mainstream biochemistry text. … The text is littered with excellent examples of the wider relevance of the material covered … . The book is exceptionally well written … I learned new things from each chapter. … a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers and instructors involved in structural biology or biophysics courses or in research on protein structure–function relationships. I would recommend it highly.―David Sheehan, ChemBioChem, 2011 The book by Kessel and Ben-Tal offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses.―Barry Honig, Columbia University, New York, New York, USA … the book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. … The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic … [and] includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. … The book provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. … it [is also] easy for experts to dive into the more specialized aspects quickly. … The book provides references to user-friendly web tools in the field. The publisher’s website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure. Perhaps also for parts of freshman biochemistry. … useful as supplement for many undergraduate and graduate courses.―Burkhard Rost, Technische Universität München, Germany
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About the Author
Dr. Amit Kessel obtained his master’s degree in experimental biochemistry at Tel-Aviv University, studying the innate response of human blood cells to pathogenic bacteria. During his Ph.D. studies he trained as a computational biologist, investigating the molecular basis of peptide-membrane interactions and the mechanisms of antibacterial peptides. In his post-doctoral research at Columbia University, Dr. Kessel continued studying proteins at the molecular level, focusing on various physicochemical aspects of protein-protein interactions. In 2010 he co-founded ES-IS Technologies, a company that designed novel enzymatic solutions for the pharmaceutical industry, and he headed the company’s R&D department. He is currently involved in several academic and industrial biotech initiatives, focusing on experimentally-guided protein structure prediction and on the in-vitro construction of protein-based nanoparticles. Prof. Nir Ben-Tal obtained his bachelor’s degree in biology, chemistry, and physics at the Hebrew University and his D.Sc. in Chemistry at the Technion, Israel Institute of Technology. He carried out his postdoctoral training as a computational biophysicist at Columbia University, and later joined the Department of Biochemistry and Molecular Biology at Tel Aviv University. His research covers various aspects of computational biology with a focus on structural bioinformatics and the protein universe. In particular, his laboratory has predicted the 3- dimensional structures of a number of transmembrane proteins, thereby providing molecular insight into their mechanisms. His lab also develops the ConSurf web-server for the detection of functional regions by mapping evolutionary data onto protein structures (jointly with the Mayrose and Pupko labs).
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Product details
Series: Chapman & Hall/CRC Mathematical and Computational Biology
Hardcover: 988 pages
Publisher: Chapman and Hall/CRC; 2 edition (April 11, 2018)
Language: English
ISBN-10: 9781498747172
ISBN-13: 978-1498747172
ASIN: 1498747175
Product Dimensions:
8.5 x 11 inches
Shipping Weight: 6 pounds (View shipping rates and policies)
Average Customer Review:
5.0 out of 5 stars
1 customer review
Amazon Best Sellers Rank:
#769,378 in Books (See Top 100 in Books)
This is the most interesting to read and complete text I have found for senior undergraduate or early graduate-level coverage of protein structure and function, and a great reference book to have on hand. I appreciate this book on so many levels! It covers:• Current computational as well as experimental methods for studying proteins, plus key databases of structural and functional information.• The theory behind our understanding of the forces and energetics underlying protein folding, stability, dynamics, ligand selectivity, and catalysis, explained in an intuitive but rigorous way.• Applications to pharmaceutical discovery and the industrial use of proteins, which are also important for those interested in careers outside academia.• All the topics in our introductory graduate course on Protein Structure, Design and Mechanism, from the determinants of structure and structure-function relationships, through kinetics and catalytic mechanisms (with the great new Chapter 9 on enzymology, which acts as a succinct text on its own), to current methods for protein structural modeling and design. In the past, we have recommended more than one text, since each one covered specific material well but was missing some other key topic. This was expensive and confusing for the students. With the 2nd edition of Kessel & Ben-Tal, the needed materials are all present in one book, whether students are new to protein structure/function or seek more depth.• The explanations are balanced by case studies that outline how these factors play out in many protein systems, including expanded coverage of G protein-coupled receptors.• A series of concept-oriented questions and problems is provided at the end of each chapter, allowing readers to assess and fill in their understanding.The color illustrations are also well designed, covering the concepts schematically along with specific examples for proteins (e.g., formation of amyloid fibrils), shown side-by-side with experimental data. While this text is significantly updated and printed in a hardcover format with easy-to-read text (larger font and pages than usual, with margins for note-taking) and comes with annotatable ebook access for free, the price is lower than several of the short paperback texts in the field. The availability of the ebook format alone for half the price will likely be attractive to students, as well as quite portable. Overall, this is a significantly enriched 2nd edition of a book we have used successfully for several years now, which I enthusiastically recommend!
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